Five of 23 women studied received intentional antenatal therapy; no malformations or genetic diseases observed<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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TUESDAY, June 6, 2023 (HealthDay News) — Most women with relapsed\/refractory lymphoma during pregnancy defer therapy and there are few obstetric or neonatal complications, according to a study published online June 1 in Blood Advances<\/em>.<\/p>\n Faheem Farooq, M.D., from Rutgers Cancer Institute of New Jersey in New Brunswick, and colleagues conducted a retrospective analysis across 10 international centers involving 23 patients with relapsed\/refractory lymphoma during pregnancy. Of the patients, 18 had classic Hodgkin lymphoma, two had peripheral T-cell lymphoma, and one each had diffuse large B-cell, follicular, and marginal zone lymphoma.<\/p>\n The researchers found that most patients chose to delay therapy until postpartum while under close surveillance, while five of the patients received intentional antenatal therapy at a median of 26 weeks of gestation; one of these received checkpoint inhibitor therapy. Nineteen live births occurred; most were born via vaginal delivery. More than half of the births were preterm (median gestation, 36 weeks), with most initiated by clinicians. The median birthweight was 2,777 g; no malformations or genetic diseases were identified. Nine patients underwent transplant postpartum. Three-year progression-free and overall survival were 24 and 83 percent, respectively, with median follow-up of 37 months.<\/p>\n “The goal of this study is to provide data that can inform patients and providers,” a coauthor said in a statement. “While a relapsed\/refractory lymphoma diagnosis during pregnancy is rare, we hope to ensure that oncologists and women have some form of guidance on how to approach this complex clinical scenario.”<\/p>\n Several authors disclosed ties to the pharmaceutical and biotechnology industries.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n