However, no associations seen for blood pressure or cholesterol levels<\/p>\n<\/h3>\n
By Lori Solomon HealthDay Reporter<\/b><\/p>\n
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FRIDAY, May 26, 2023 (HealthDay News) — Higher poststroke glucose levels are associated with faster subsequent global cognitive decline, according to research published online May 17 in JAMA Network Open<\/em>.<\/p>\n Deborah A. Levine, M.D., M.P.H., from the University of Michigan in Ann Arbor, and colleagues conducted a meta-analysis using individual participant data from 982 stroke survivors from four cohort studies to estimate changes in cognition after incident stroke (median follow-up, 4.7 years).<\/p>\n The researchers found that cumulative mean poststroke systolic blood pressure and low-density lipoprotein cholesterol levels were not associated with any cognitive outcome. A higher cumulative mean poststroke glucose level was associated with faster decline in global cognition when adjusting for cumulative mean poststroke systolic blood pressure and low-density lipoprotein cholesterol levels (\u00e2\u0088\u00920.04 points\/year faster per each 10-mg\/dL increase). No associations were seen for glucose and executive function or memory. Results were similar when controlling for apolipoprotein E4 and apolipoprotein E4 \u0097 time.<\/p>\n “These findings suggest that higher cumulative glucose levels may contribute to faster cognitive decline in stroke survivors, representing a potential treatment target to preserve cognition after stroke,” the authors write.<\/p>\n Several authors disclosed funding and personal fees from various organizations. <\/p>\n