Combination better than chemoimmunotherapy for percentage with undetectable minimal residual disease, PFS in chronic lymphocytic leukemia <\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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THURSDAY, May 11, 2023 (HealthDay News) — For fit patients with chronic lymphocytic leukemia (CLL), venetoclax-obinutuzumab with or without ibrutinib, is superior to chemoimmunotherapy as first-line treatment, according to a study published in the May 11 issue of the New England Journal of Medicine<\/em>.<\/em><\/p>\n Barbara Eichhorst, M.D., from the University of Cologne in Germany, and colleagues randomly assigned fit patients with CLL who did not have TP53<\/em> aberrations to receive six cycles of chemoimmunotherapy (fludarabine-cyclophosphamide-rituximab or bendamustine-rituximab) or 12 cycles of venetoclax-rituximab, venetoclax-obinutuzumab, or venetoclax-obinutuzumab-ibrutinib (229, 237, 229, and 231 patients, respectively).<\/p>\n The researchers found that the percentage of patients with undetectable minimal residual disease was significantly higher in the venetoclax-obinutuzumab group and the venetoclax-obinutuzumab-ibrutinib group than in the chemoimmunotherapy group (86.5 and 92.2 percent, respectively, versus 52.0 percent), but it was not higher in the venetoclax-rituximab group (57.0 percent). Three-year progression-free survival was 90.5 and 87.7 percent in the venetoclax-obinutuzumab-ibrutinib and venetoclax-obinutuzumab groups, respectively, compared with 75.5 percent in the chemoimmunotherapy group (hazard ratios for disease progression or death, 0.32 and 0.42, respectively), but it was not significantly higher with venetoclax-rituximab (80.8 percent). Grade 3 and 4 infections occurred more often with chemoimmunotherapy and venetoclax-obinutuzumab-ibrutinib than with venetoclax-rituximab or venetoclax-obinutuzumab (18.5, 21.2, 10.5, and 13.2 percent, respectively).<\/p>\n “In patients with a low burden of coexisting conditions, time-limited venetoclax-obinutuzumab with or without ibrutinib was superior to chemoimmunotherapy with respect to inducing undetectable minimal residual disease and longer progression-free survival,” the authors write.<\/p>\n The study was supported by grants from AbbVie, Janssen, and Roche, which provided some of the study medications.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n