Immediate treatment before 20 weeks of gestation led to slightly lower incidence of composite of neonatal outcomes<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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TUESDAY, May 9, 2023 (HealthDay News) — Immediate treatment of gestational diabetes before 20 weeks of gestation leads to a slightly lower incidence of a composite of adverse neonatal outcomes but no significant difference in pregnancy-related hypertension or neonatal lean body mass, according to a study published online May 5 in the New England Journal of Medicine<\/em>. The research was published to coincide with the 11th International DIP Symposium on Diabetes, Hypertension, Metabolic Syndrome & Pregnancy: Innovative Approaches in Maternal Offspring Health, held from May 4 to 6 in Thessaloniki, Greece.<\/em><\/p>\n David Simmons, M.D., from Western Sydney University, and colleagues randomly assigned 802 women between 4 weeks and 19 weeks\/6 days of gestation who had a risk factor for hyperglycemia and a diagnosis of gestational diabetes to receive immediate treatment or deferred or no treatment for gestational diabetes (406 and 396 women, respectively).<\/p>\n The researchers found that an adverse neonatal outcome event occurred in 24.9 and 30.5 percent of women in the immediate-treatment and control groups, respectively (adjusted risk difference, \u00e2\u0088\u00925.6 percentage points; 95 percent confidence interval, \u00e2\u0088\u009210.1 to \u00e2\u0088\u00921.2). Pregnancy-related hypertension occurred in 10.6 and 9.9 percent in the immediate-treatment and control groups, respectively (adjusted risk difference, 0.7 percentage points; 95 percent confidence interval, \u00e2\u0088\u00921.6 to 2.9). The mean neonatal lean body mass was 2.86 g and 2.91 g in the immediate-treatment and control groups, respectively (adjusted mean difference, \u00e2\u0088\u00920.04 g; 95 percent confidence interval, \u00e2\u0088\u00920.09 to 0.02). With respect to serious adverse events associated with screening and treatment, no between-group differences were observed.<\/p>\n “Confirmatory trials and long-term follow-up studies of the offspring are warranted,” the authors write.<\/p>\n One author disclosed financial ties to the pharmaceutical industry.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n