No association seen between vaccine and menstrual changes requiring health care contact in large study of nearly 3 million women in Sweden<\/p>\n<\/h3>\n
By Lori Solomon HealthDay Reporter<\/b><\/p>\n
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MONDAY, May 8, 2023 (HealthDay News) — COVID-19 vaccines are not clearly associated with menstrual changes requiring health care attention, according to a study published online May 3 in The BMJ<\/em>.<\/p>\n Rickard Ljung, M.D., Ph.D., from the Karolinska Institutet in Stockholm, and colleagues evaluated the risks for any menstrual disturbance and bleeding following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination in women. The analysis included data from 2.9 million Swedish women (aged 12 to 74 years).<\/p>\n The researchers found the risks for bleeding in women who were postmenopausal were highest after the third dose, in the one-to-seven-day risk window (hazard ratio [HR], 1.28) and in the eight-to-90-day risk window (HR, 1.25). Results largely persisted after adjusting for covariates. A 23 to 33 percent increased risk for postmenopausal bleeding after eight to 90 days was suggested following the third dose of BNT162b2 and mRNA-1273. The association was less clear with the ChAdOx1 nCoV-19 vaccine. Adjusting for covariates almost completely removed the weak associations seen in crude analyses for menstrual disturbance or bleeding in women who were premenopausal.<\/p>\n “These findings do not provide substantial support for a causal association between SARS-CoV-2 vaccination and health care contacts related to menstrual or bleeding disorders,” the authors write.<\/p>\n Several authors disclosed financial ties to the pharmaceutical industry.<\/p>\n