Authors say finding may be explained by early-life gut dysbiosis<\/p>\n<\/h3>\n
By Lori Solomon HealthDay Reporter<\/b><\/p>\n
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TUESDAY, May 2, 2023 (HealthDay News) — Birth by cesarean delivery is associated with early-onset colorectal cancer (CRC) only in female offspring, according to a study published online April 27 in JAMA Network Open<\/em>.<\/p>\n Yin Cao, Sc.D., M.P.H., from the Washington University School of Medicine in St. Louis, and colleagues prospectively examined the association between birth by cesarean delivery and early-onset CRC (between 18 and 49 years of age from 1991 to 2017) among offspring. The analysis included 564 adults diagnosed with early-onset CRC and 2,180 matched controls.<\/p>\n The researchers found that compared with vaginal delivery, birth by cesarean delivery was not associated with early-onset CRC in the overall population (adjusted odds ratio, 1.28; 95 percent confidence interval, 0.91 to 1.79) when adjusting for matching and maternal and pregnancy-related factors. There was a positive association seen for female offspring (adjusted odds ratio, 1.62; 95 percent confidence interval, 1.01 to 2.60); however, no association was observed for male offspring (adjusted odds ratio, 1.05; 95 percent confidence interval, 0.64 to 1.72).<\/p>\n “In this study, females born by cesarean delivery had greater odds of early-onset CRC, suggesting that early-life gut dysbiosis may contribute to early-onset CRC in females,” the authors write.<\/p>\n Two authors disclosed financial ties to the pharmaceutical industry.<\/p>\n