For people with temporal lobe epilepsy, odds of worse cognitive phenotype seen for those in more disadvantaged ADI quintiles<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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WEDNESDAY, April 19, 2023 (HealthDay News) — For people with temporal lobe epilepsy (TLE), neighborhood deprivation is associated with worse cognitive outcomes, according to a study published online April 19 in Neurology<\/em>.<\/p>\n Robyn M. Busch, Ph.D., from the Cleveland Clinic, and colleagues examined the association between neighborhood deprivation and neuropsychological function in 800 adults with TLE in a cross-sectional study. Neuropsychological data, including measures of intelligence, attention, processing speed, language, executive function, visuospatial skills, verbal\/visual memory, depression, and anxiety, were obtained from a clinical registry. The Area Deprivation Index (ADI) was calculated for each individual using home addresses.<\/p>\n The researchers found that across nearly all measured cognitive domains, effects of disadvantage (increasing ADI) were seen, along with significant increases in symptoms of depression and anxiety. Increased odds of a worse cognitive phenotype were seen for patients in more disadvantaged ADI quintiles. In the most disadvantaged quintiles, patients who self-identified as being members of minoritized groups were over-represented; compared with non-Hispanic Whites, patients in these groups had a 2.91-fold increased likelihood of being in a severe cognitive phenotype. This relationship was attenuated after accounting for ADI, indicating that neighborhood deprivation accounts for some of the association between race\/ethnicity and cognitive phenotype (odds ratio after adjustment for ADI, 1.82).<\/p>\n “Epilepsy research has arguably ignored the potential impact of the social determinants of health in neighborhoods on cognition — factors that have been hiding in plain sight for many years,” Busch said in a statement. “Our study shows that these neighborhood social factors are linked to epilepsy outcomes.”<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n