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WEDNESDAY, Feb. 21, 2018 (HealthDay News) — Perioperative glucose predicts 30-day mortality linearly in noncardiac surgical patients and nonlinearly in cardiac surgical patients, according to a study published online Feb. 13 in Diabetes Care<\/i>.<\/p>\n
Willem van den Boom, from Duke University in Durham, N.C., and colleagues assessed the association of preoperative hemoglobin A1c (A1C) with perioperative glucose control and their relationship with 30-day mortality among 6,684 noncardiac and 6,393 cardiac surgeries.<\/p>\n
The researchers found that A1C and glucose were strongly associated. For noncardiac cases, glucose and mortality were positively associated with 1.0 percent mortality at mean glucose of 100 mg\/dL and 1.6 percent at mean glucose of 200 mg\/dL. There was a striking U-shaped relationship between glucose and mortality among cardiac patients, with 4.5 percent mortality at 100 mg\/dL to 1.5 percent at 140 mg\/dL and 6.9 percent at 200 mg\/dL. When controlling for glucose, A1C and 30-day mortality were not associated in either noncardiac or cardiac procedures.<\/p>\n
“This confirms that perioperative glucose control is related to surgical outcomes, but that A1C, reflecting antecedent glycemia, is a less useful predictor,” the authors write.<\/p>\n
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