Subset of alpha-gal allergic patients show gastrointestinal symptoms without skin changes or anaphylaxis<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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TUESDAY, April 4, 2023 (HealthDay News) — A subset of patients with alpha-gal allergy have gastrointestinal symptoms without skin changes or anaphylaxis, according to a clinical practice update published in the April issue of Clinical Gastroenterology and Hepatology<\/em>.<\/p>\n Sarah K. McGill, M.D., from the University of North Carolina at Chapel Hill, and colleagues provide information relating to the presentation and management of alpha-gal syndrome in order to increase awareness among gastroenterologists.<\/p>\n The authors note that a subset of alpha-gal allergic patients show gastrointestinal symptoms, such as abdominal pain, diarrhea, nausea, or vomiting, without skin changes or anaphylaxis. Among patients with gastrointestinal distress and increased serum alpha-gal immunoglobulin E (IgE) antibodies whose symptoms are relieved adequately on an alpha-gal avoidance diet, which eliminates pork, beef, and mammalian-derived products, alpha-gal syndrome can be diagnosed. Counseling for an alpha-gal avoidance diet is suggested for patients with suspected alpha-gal allergy because it is the primary management. Measures to avoid tick bites should also be included in counseling, because additional bites can cause a further increase in alpha-gal IgE titers and worsen the allergy. Referral to allergists is recommended for patients who also have reactions such as facial swelling, urticaria, and respiratory difficulty.<\/p>\n “It is important for gastroenterologists to be aware of this condition and to be capable of diagnosing and treating it in a timely manner,” the authors write.<\/p>\n Two authors disclosed financial ties to the medical technology industry.<\/p>\n