Findings show most children achieve clinically significant peanut desensitization from 4-mg dose over four years<\/p>\n<\/h3>\n
By Lori Solomon HealthDay Reporter<\/b><\/p>\n
<\/b><\/p>\n
MONDAY, April 3, 2023 (HealthDay News) — Peanut sublingual immunotherapy (SLIT) is safe in children and leads to clinically significant desensitization in most patients, according to a study published online Feb. 22 in the Journal of Allergy and Clinical Immunology<\/em>.<\/p>\n Edwin H. Kim, M.D., from the University of North Carolina School of Medicine in Chapel Hill, and colleagues evaluated the efficacy and safety of 4-mg peanut SLIT and persistence of desensitization after SLIT discontinuation. The analysis included 47 peanut-allergic children (aged 1 to 11 years) treated for 48 months.<\/p>\n The researchers reported that the mean successfully consumed dose (SCD) during the placebo-controlled food challenge increased from 48 to 2,723 mg of peanut protein after SLIT, with 70 percent achieving clinically significant desensitization (SCD > 800 mg) and 36 percent achieving full desensitization (SCD = 5,000 mg). The median time to loss of clinically significant desensitization was 22 weeks. Compared with baseline, the peanut skin prick test; peanut-specific immunoglobulin (Ig)E, IgG4, and IgG4\/IgE ratio; and peanut-stimulated basophil activation test, interleukin (IL)-4, IL-5, IL-13, interferon-\u00ce\u00b3, and IL-10 changed significantly, with changes seen as early as six months. Transient oropharyngeal itching was the most common reaction, with a median rate of reaction per dose of 0.5 percent and no dosing symptoms requiring epinephrine.<\/p>\n “In this open-label, prospective study, peanut SLIT was safe and induced clinically significant desensitization in most of the children, lasting more than 17 weeks after discontinuation of therapy,” the authors write.<\/p>\n Several authors disclosed financial ties to the pharmaceutical and biotechnology industries.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n