Odds of miscarriage were increased by 1.5 percent per delayed Carnegie stage<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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MONDAY, March 27, 2023 (HealthDay News) — In live pregnancies ending in a miscarriage, embryonic morphological development is delayed, according to a study published online March 26 in Human Reproduction<\/em>.<\/p>\n Carsten S. Pietersma, from the University Medical Center Rotterdam in the Netherlands, and colleagues enrolled 644 women with singleton pregnancies in the periconception period in a prospective cohort study with follow-up until one year after delivery. Early morphologic development was assessed by the Carnegie developmental stages and was compared in pregnancies ending in a miscarriage and ongoing pregnancies.<\/p>\n Of the pregnancies, 611 were ongoing and 33 ended in a miscarriage, yielding 1,127 assigned Carnegie stages for evaluation. The researchers found that a pregnancy ending in a miscarriage was associated with a lower Carnegie stage compared with an ongoing pregnancy (\u00ce\u00b2Carnegie<\/sub> = \u00e2\u0088\u00920.824). Compared with an ongoing pregnancy, a live embryo of a pregnancy ending in a miscarriage reached the final Carnegie stage with a delay of 4.0 days. A smaller crown-rump length and embryonic volume were seen in association with pregnancy ending in miscarriage. The odds of miscarriage were increased by 1.5 percent per delayed Carnegie stage (odds ratioCarnegie<\/sub> = 1.015).<\/p>\n “In the future, embryonic morphology may be used as a parameter for estimating the likelihood of a pregnancy continuing to the delivery of a healthy baby, which is of crucial importance for all women but in particular for those at risk of a recurrent pregnancy loss,” the authors write.<\/p>\n