Placement at two to four weeks postpartum noninferior to six to eight weeks postpartum for complete expulsion<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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THURSDAY, March 23, 2023 (HealthDay News) — Intrauterine device (IUD) placement at two to four weeks postpartum is noninferior to placement at six to eight weeks postpartum for complete expulsion, according to a study published in the March 21 issue of the Journal of the American Medical Association<\/em>.<\/p>\n Sarah Averbach, M.D., from the University of California San Diego in La Jolla, and colleagues conducted a randomized, noninferiority trial involving people who had a vaginal or cesarean birth to assess expulsion rates for IUDs placed early postpartum compared to those placed at the standard interval six-week visit. A total of 404 participants were enrolled and randomly assigned to early IUD placement (14 to 28 days; 203 participants) or interval IUD placement (42 to 56 days; 201 participants).<\/p>\n The primary outcome was complete IUD expulsion by six months postpartum; the noninferiority margin was 6 percent. Of the 294 participants who received an IUD and completed six-month follow-up, the researchers found that the complete expulsion rates were 2.0 and 0 percent in the early and interval placement groups, respectively (between-group difference, 2.0 [95 percent confidence interval, \u00e2\u0088\u00920.05 to 5.7] percentage points). Partial expulsion occurred in 9.4 and 7.6 percent of participants in the early and interval placement groups, respectively (between-group difference, 1.8 [95 percent confidence interval, \u00e2\u0088\u00924.8 to 8.6] percentage points). At six months, IUD use was similar between the groups (69.5 and 67.2 percent, respectively).<\/p>\n “The early placement group in this study had a small absolute increase in risk of partial expulsion, which did not meet the prespecified criterion for noninferiority,” the authors write.<\/p>\n One author disclosed financial ties to Bayer Pharmaceuticals.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n