Greater percentage of time with glucose level in target range seen for young children using closed-loop system<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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FRIDAY, March 17, 2023 (HealthDay News) — For young children with type 1 diabetes, a closed-loop glucose system results in a higher percentage of time that the glucose level is in the target range, according to a study published in the March 16 issue of the New England Journal of Medicine<\/em>.<\/p>\n R. Paul Wadwa, M.D., from the University of Colorado in Aurora, and colleagues randomly assigned 102 children who were at least 2 years of age but younger than 6 years with type 1 diabetes to receive treatment with a closed-loop system of insulin delivery or standard care, including either an insulin pump or multiple daily injections of insulin plus a continuous glucose monitor, in a 13-week multicenter trial (68 and 34 patients, respectively). In 81 percent of the patients, initiation of the closed-loop system was virtual.<\/p>\n The researchers found that from baseline to during the 13-week follow-up period, the mean percentage of time that the glucose level was within the target range increased from 56.7 to 69.3 percent in the closed-loop group and from 54.9 to 55.9 percent in the standard-care group (mean adjusted difference, 12.4 percentage points; equivalent to about three hours per day). Similar treatment effects were seen for the percentage of time that the glucose level was >250 mg\/dL, on the mean glucose level, and on the glycated hemoglobin level; no significant difference was seen between the groups in the percentage of time that the glucose level was <70 mg\/dL.<\/p>\n “These results suggest that in very young children, closed-loop systems are superior to standard care with respect to glucose control,” writes the author of an accompanying editorial.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n