Declines in global cognition, language, attention z-score greater for women with preeclampsia\/eclampsia on stratification by HDP type<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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MONDAY, March 6, 2023 (HealthDay News) — Women with hypertensive disorders of pregnancy (HDP), specifically preeclampsia\/eclampsia (PE\/E), have greater declines in global cognition later in life, according to a study published online March 1 in Neurology<\/em>.<\/p>\n Michelle M. Mielke, Ph.D., from the Wake Forest University School of Medicine in Winston-Salem, North Carolina, and colleagues examined the effects of any HDP, gestational or chronic hypertension (GH\/CH), PE\/E, and nulliparity on cognition in later life in a study involving 2,239 women enrolled in the Mayo Clinic Study of Aging with abstracted pregnancy information. Every 15 months, a cognitive battery of nine tests was conducted.<\/p>\n Of the participants, 1,854 (82.8 percent) had at least one pregnancy (1,607 all normotensive, 100 GH\/CH, 147 PE\/E) and 385 were nulliparous (17.2 percent). The researchers observed no cross-sectional difference in cognitive performance for women with a history of any HDP, GH\/CH, or PE\/E versus normotensive women; lower global and domain-specific cognition were seen for nulliparous women in age- and education-adjusted models, with an interaction seen for nulliparity and education. Compared with women with all normotensive pregnancies, longitudinally, women with any HDP had greater declines in global cognition and attention\/executive z-scores. When stratified by HDP type, greater declines in global cognition, language, and attention z-scores were seen for women with PE\/E only.<\/p>\n “While high blood pressure during pregnancy, including preeclampsia, is recognized as a risk factor for heart disease and stroke, our study suggests that it may also be a risk factor for cognitive decline in later life,” Mielke said in a statement.<\/p>\n One author disclosed financial ties to the biopharmaceutical industry.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n