Reduction in risk was greatest for those with history of ischemic heart disease or stroke<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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THURSDAY, Feb. 16, 2023 (HealthDay News) — For patients with diabetes mellitus (DM), pioglitazone use is associated with a reduced risk for dementia, especially in those with a history of ischemic heart disease or stroke, according to a study published online Feb. 15 in Neurology<\/em>.<\/em><\/p>\n Junghee Ha, M.D., Ph.D., from the Yonsei University College of Medicine in Seoul, South Korea, and colleagues examined the effects of pioglitazone use on dementia in patients with new-onset type 2 DM using data from the Korean National Health Insurance Service DM cohort (2002 to 2017). The extent to which incident stroke affects the association between pioglitazone use and dementia was assessed.<\/p>\n The researchers found that compared with nonuse, pioglitazone use was associated with a reduced risk for dementia (adjusted hazard ratio, 0.84); patients with a history of ischemic heart disease or stroke before DM onset had a greater risk reduction in dementia (adjusted hazard ratios, 0.46 and 0.57, respectively). Pioglitazone use was also associated with a reduced risk for stroke incidence (adjusted hazard ratio, 0.81). However, a lowered risk for dementia was not seen when stroke developed during the observation period of pioglitazone use.<\/p>\n “These results provide valuable information on who could potentially benefit from pioglitazone use for prevention of dementia,” a coauthor said in a statement. “In some previous studies of people with dementia or at risk of cognitive decline who did not have diabetes, pioglitazone did not show any protection against dementia, so it’s likely that a critical factor affecting the effectiveness is the presence of diabetes.”<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n