Ten-year overall survival is 63.5 percent; only persistent opioid use associated with worse overall survival in multivariable modeling<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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WEDNESDAY, Feb. 15, 2023 (HealthDay News) — Ten-year overall survival is 63.5 percent among patients undergoing operative intervention for chronic pancreatitis, according to a study published online Jan. 24 in the Journal of the American College of Surgeons<\/em>.<\/p>\n Gregory C. Wilson, M.D., from the University of Cincinnati College of Medicine, and colleagues examined survival among patients who underwent operative intervention at a single institution between 2000 and 2020 for chronic pancreatitis. Data were included for 493 patients who underwent 555 operative interventions: 48.5 percent underwent total pancreatectomy \u00c2\u00b1 islet auto transplantation.<\/p>\n The most common etiology of chronic pancreatitis was idiopathic, followed by alcohol and known genetic polymorphisms (41.8, 28.0, and 9.9 percent, respectively). With a median follow-up of 83.9 months, the researchers found that median overall survival was 202.7 months, with a five- and 10-year overall survival of 81.3 and 63.5 percent. A total of 165 patients were deceased, with infections, cardiovascular disease, and diabetes-related causes the most common causes of death (16.4, 12.7, and 10.9 percent, respectively). Overall, 73.1 percent of the patients remained opioid-free on long-term follow-up and 58.7 percent had insulin-dependent diabetes. Only persistent opioid use was associated with worse overall survival in multivariate Cox-proportional hazards modeling (hazard ratio, 3.91).<\/p>\n “There’s more than just surgery in the care of these patients,” Wilson said in a statement. “There’s a second part to all of this and the study highlights some of these findings that are important, such as the diabetic-related causes of death, cardiovascular disease, even some of the cancers that show up.”<\/p>\n