Improved glucose control seen with no increase in hypoglycemia compared with standard insulin therapy<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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FRIDAY, Jan. 27, 2023 (HealthDay News) — For adults with type 2 diabetes, a fully closed-loop insulin delivery system improves glucose control without increasing hypoglycemia compared with standard insulin therapy, according to a study published online Jan. 11 in Nature Medicine<\/em>.<\/p>\n Aideen B. Daly, M.B.B.S., from the Wellcome-MRC Institute of Metabolic Science at Addenbrooke’s Hospital in Cambridge, England, and colleagues conducted a randomized crossover study to compare eight weeks of the CamAPS HX fully closed-loop app with standard insulin therapy and a masked glucose sensor (control). A two- to four-week washout period separated the treatments. Twenty-eight participants were randomly assigned to two groups (14 each to closed-loop therapy first and control therapy first).<\/p>\n The researchers found that the proportion of time in the target glucose range (3.9 to 10.0 mmol l-1<\/sup>) was 66.3 \u00c2\u00b1 14.9 percent and 32.3 \u00c2\u00b1 24.7 percent with closed-loop therapy and control therapy, respectively. Time >10.0 mmol l-1<\/sup> was 33.2 \u00c2\u00b1 14.8 and 67.0 \u00c2\u00b1 25.2 percent with closed-loop therapy and control therapy, respectively. Compared with the control period, mean glucose was lower during the closed-loop therapy period (9.2 \u00c2\u00b1 1.2 mmol l-1<\/sup> versus 12.6 \u00c2\u00b1 3.0 mmol l\u00e2\u0080\u00911<\/sup>). In addition, hemoglobin A1c was lower following closed-loop versus control therapy (57 \u00c2\u00b1 9 mmol mol-1<\/sup> versus 72 \u00c2\u00b1 13 mmol mol-1<\/sup>). The groups had a similar time <3.9 mmol l-1<\/sup>. Severe hypoglycemia events did not occur in either period.<\/p>\n “This study suggests that fully closed-loop insulin delivery is a safe and efficacious approach to manage type 2 diabetes in adults,” the authors write.<\/p>\n Dexcom supplied discounted continuous glucose monitoring devices and sensors for the study.<\/p>\n