No significant difference seen in all-cause mortality or all-cause hospitalization over 12 months<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
<\/b><\/p>\n
TUESDAY, Jan. 24, 2023 (HealthDay News) — For patients hospitalized for heart failure, all-cause mortality does not differ significantly at 12 months for those receiving torsemide or furosemide, according to a study published in the Jan. 17 issue of the Journal of the American Medical Association<\/em>.<\/p>\n Robert J. Mentz, M.D., from the Duke Clinical Research Institute in Durham, North Carolina, and colleagues compared torsemide and furosemide among 2,859 patients hospitalized for heart failure in an open-label randomized trial conducted at 60 hospitals. <\/p>\n The researchers found that death occurred in 26.1 and 26.2 percent of 1,431 and 1,428 patients in the torsemide and furosemide groups, respectively (hazard ratio, 1.02; 95 percent confidence interval, 0.89 to 1.18). All-cause mortality or all-cause hospitalization occurred in 47.3 and 49.3 percent of patients in the torsemide and furosemide groups, respectively (hazard ratio, 0.92; 95 percent confidence interval, 0.83 to 1.02). Overall, there were 940 and 987 total hospitalizations among 536 and 577 participants in the torsemide and furosemide groups, respectively (rate ratio, 0.94; 95 percent confidence interval, 0.84 to 1.07). Similar results were seen in prespecified subgroups.<\/p>\n “Our study showed that torsemide did not improve survival compared to furosemide in this high-risk population of patients with heart failure, and we also observed similar rates of hospitalization with the two medications,” Mentz said in a statement.<\/p>\n Several authors disclosed financial ties to the biopharmaceutical industry.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n