Decreased survival seen for both underweight and severe obesity in newly diagnosed patients<\/p>\n<\/h3>\n
By Lori Solomon HealthDay Reporter<\/b><\/p>\n
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FRIDAY, Jan. 20, 2023 (HealthDay News) — Underweight and severe obesity are associated with decreased survival in patients with multiple myeloma (MM), according to a study published online Jan. 12 in the Blood Cancer Journal<\/em>.<\/p>\n Urvi A. Shah, M.D., from the Memorial Sloan Kettering Cancer Center in New York City, and colleagues assessed the impact of body mass index (BMI) on progression-free survival (PFS) and overall survival (OS) in patients with newly diagnosed MM. The analysis included data from 1,142 patients from the Multiple Myeloma Research Foundation CoMMpass registry.<\/p>\n The researchers found that both patients with underweight and severe obesity had lower median PFS and OS than patients with normal weight, overweight, and moderate obesity. Patients with underweight had a significantly higher risk for death in models associating PFS and OS with BMI (hazard ratio [HR], 2.32; 95 percent confidence interval [CI], 1.09 to 4.97). Patients with severe obesity tended to have a higher for risk of progression (HR, 1.29; 95 percent CI, 0.99 to 1.67) and death (HR, 1.43; 95 percent CI, 0.98 to 2.08) versus patients with normal BMI. OS worsened with higher comorbidities (three-year OS for Charlson Comorbidity Index [CCI] \u00e2\u0089\u00a55: 65 percent; CCI >2 to <5: 87 percent; CCI \u00e2\u0089\u00a42: 87 percent). Frailty was also significantly associated with worse OS (three-year OS for frail versus nonfrail: 70 versus 88 percent). When accounting for CCI, there was a trend toward decreased OS in the underweight group versus the normal-weight group (HR, 2.12; 95 percent CI, 0.99 to 4.53).<\/p>\n “Clinical research to understand if patients with extreme BMI may benefit from weight management strategies to improve outcomes may be of importance,” the authors write<\/p>\n