No significant improvement seen in survival with gemcitabine and cisplatin for patients with locally advanced disease, gallbladder adenocarcinoma<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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MONDAY, Jan. 23, 2023 (HealthDay News) — For patients with biliary tract cancer (BTC), no significant improvement is observed in overall survival with the addition of albumin-bound paclitaxel to gemcitabine and cisplatin (GAP) versus gemcitabine\/cisplatin (GC), according to a study presented at the American Society of Clinical Oncology annual Gastrointestinal Cancers Symposium, held from Jan. 19 to 21 in San Francisco.<\/p>\n
Rachna T. Shroff, M.D., from the University of Arizona in Tucson, and colleagues conducted a randomized phase III trial comparing GAP to GC among newly diagnosed advanced BTC patients. A total of 441 patients (73 percent with metastases) were randomly assigned in a 2:1 ratio to either GAP or GC and were treated until progression.<\/p>\n
The researchers found that the median overall survival was 14 and 12.7 months for GAP and GC, respectively (hazard ratio, 0.93; 95 percent confidence interval, 0.74 to 1.19; P = 0.58); the overall response rate (confirmed and nonconfirmed) was 34 and 25 percent, respectively (P = 0.11), and median progression-free survival was 8.2 and 6.4 months, respectively (hazard ratio, 0.92; 95 percent confidence interval, 0.72 to 1.16; P = 0.47). In exploratory subset analyses, overall survival was improved with GAP versus GC in patients with locally advanced disease (median, 19.2 versus 13.7 months; hazard ratio, 0.67; 95 percent confidence interval, 0.42 to 1.06; P = 0.09) and in patients with gallbladder adenocarcinoma (median, 17.0 versus 9.3 months; hazard ratio, 0.74; 95 percent confidence interval, 0.41 to 1.35; P = 0.33).<\/p>\n
“While the addition of nab-paclitaxel did not improve survival, the triplet may merit further investigation in locally advanced biliary cancers as a potential neoadjuvant approach,” Shroff said in a statement.<\/p>\n
The study was partially funded by Celgene, a subsidiary of Bristol Myer Squibb, the manufacturer of nab-paclitaxel.<\/p>\n
Press Release<\/a><\/p>\n