No significant difference seen in incidence of death, deep vein thrombosis, pulmonary embolism, bleeding complications<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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FRIDAY, Jan. 20, 2023 (HealthDay News) — For patients with orthopedic trauma, thromboprophylaxis with aspirin is noninferior to low-molecular-weight heparin for preventing death, according to a study published in the Jan. 19 issue of the New England Journal of Medicine<\/em>.<\/p>\n Robert V. O’Toole, M.D., from the University of Maryland School of Medicine in Baltimore, and colleagues conducted a randomized, noninferiority trial involving adult patients who had a fracture of an extremity that had been treated operatively or any pelvic or acetabular fracture. Patients were randomly assigned to receive either low-molecular-weight heparin or aspirin while they were in the hospital (6,110 and 6,101 patients, respectively). The patients continued to receive thromboprophylaxis after discharge according to the hospital clinical protocol.<\/p>\n The researchers found that death at 90 days occurred in 0.78 and 0.73 percent of patients in the aspirin and low-molecular-weight heparin groups, respectively (difference, 0.05 percentage points; 96.2 percent confidence interval, \u00e2\u0088\u00920.27 to 0.38; P < 0.001 for noninferiority). Deep vein thrombosis occurred in 2.51 and 1.71 percent of patients in the aspirin and low-molecular-weight heparin groups, respectively. The groups had a similar incidence of pulmonary embolism, bleeding complications, and other serious adverse events.<\/p>\n “The findings in this trial clearly indicate that guidelines for the prevention of hospital-acquired venous thromboembolism will need to be rewritten to include the option of aspirin in patients with traumatic injuries,” write the authors of an accompanying editorial.<\/p>\n Several authors disclosed financial ties to the medical device and health care industries.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n