Benefits seen for genitourinary and gastrointestinal toxic effects<\/p>\n<\/h3>\n
By Lori Solomon HealthDay Reporter<\/b><\/p>\n
<\/b><\/p>\n
WEDNESDAY, Jan. 18, 2023 (HealthDay News) — Magnetic resonance imaging (MRI)-guided radiotherapy offers significant benefit over computed tomography (CT)-guided therapy for treatment of prostate cancer, according to a study published online Jan. 12 in JAMA Oncology<\/em>.<\/p>\n Amar U. Kishan, M.D., from University of California in Los Angeles, and colleagues assessed whether aggressive margin reduction with MRI guidance significantly reduces acute grade 2 or greater genitourinary toxic effects after prostate stereotactic body radiotherapy (SBRT) versus CT guidance (79 versus 77 patients). A prespecified interim futility analysis was conducted after 100 patients reached \u00e2\u0089\u00a590 days after SBRT.<\/p>\n The researchers found that the incidence of acute grade 2 or greater genitourinary toxic effects was significantly lower with MRI versus CT guidance (24.4 versus 43.4 percent), as was the incidence of acute grade 2 or greater gastrointestinal toxic effects (0.0 versus 10.5 percent). At one month, MRI guidance was associated with a significantly smaller percentage of patients with a \u00e2\u0089\u00a515-point increase in the International Prostate Symptom Score (6.8 versus 19.4 percent) and a significantly reduced percentage of patients with a clinically significant (\u00e2\u0089\u00a512-point) decrease in Expanded Prostate Cancer Index Composite-26 bowel scores (25 versus 50 percent).<\/p>\n “In this randomized clinical trial, compared with CT-guidance, MRI-guided SBRT significantly reduced both moderate acute physician-scored toxic effects and decrements in patient-reported quality of life,” the authors write. “Longer-term follow-up will confirm whether these notable benefits persist.”<\/p>\n Several authors disclosed financial ties to ViewRay, maker of the MRI-guided radiation therapy system used in the study.<\/p>\n Abstract\/Full Text<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n