Cluster of inflammation markers positively associated with multiple sclerosis-related species<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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MONDAY, Jan. 9, 2023 (HealthDay News) — Considerable alterations in the gut microbiota are seen in patients with multiple sclerosis, according to a study published online Jan. 5 in Genome Medicine<\/em>.<\/p>\n Florence Thirion, from Universit \u00a9 Paris-Saclay, and colleagues conducted a case-control study involving 148 Danish cases with multiple sclerosis and 148 matched healthy controls to examine the characteristics of gut microbiota in multiple sclerosis and its association with disease variables.<\/p>\n The researchers found that when comparing all multiple sclerosis cases with healthy controls, 61 bacterial species were abundantly different, and of these, 31 species were enriched in cases. There was a positive association seen for a cluster of inflammatory markers composed of blood leukocytes, C-reactive protein, and blood cell gene expression of IL17A<\/em> and IL6<\/em> with a cluster of multiple sclerosis-related species. In cases with disease-active treatment-naive multiple sclerosis, bacterial species that were more abundant were positively linked to a group of plasma cytokines including interleukin (IL)-22, IL-17A, interferon-\u00ce\u00b2, IL-33, and tumor necrosis factor-\u00ce\u00b1. There was an association observed for the bacterial species richness of treatment-naive multiple sclerosis cases with the number of relapses during a two-year period. In cases without active disease, the absolute abundance of two bacterial species (Faecalibacterium prausnitzii <\/em>and Gordonibacter urolithinfaciens<\/em>), known to produce anti-inflammatory metabolites, was enriched. Higher viral species diversity and higher abundance of Caudovirales<\/em> bacteriophages were seen in cases with multiple sclerosis.<\/p>\n “Perhaps in the long term, patients will be able to take dietary supplements that promote development of the right intestinal bacteria, or we can take intestinal bacteria that promote a favorable metabolism in the intestine,” a coauthor said in a statement.<\/p>\n