Serious adverse events are rare, occur more often with mifepristone-misoprostol versus procedural induced abortion in first trimester<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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TUESDAY, Jan. 3, 2023 (HealthDay News) — For women undergoing first-trimester induced abortion (IA), short-term adverse events are more likely among those prescribed mifepristone-misoprostol than procedural IA, according to a study published online Jan. 3 in the Annals of Internal Medicine<\/em>.<\/p>\n Ning Liu, Ph.D., and Joel G. Ray, M.D., from the University of Toronto, compared the short-term risk for adverse outcomes after first-trimester IA by mifepristone-misoprostol versus procedural IA. Comparison 1 included 39,856 women dispensed mifepristone-misoprostol as outpatients and 65,176 women undergoing procedural IA at 14 weeks of gestation or earlier. Comparison 2 included 39,856 women prescribed mifepristone-misoprostol and 8,861 women undergoing ambulatory hospital-based procedural IA at an estimated 9 weeks of gestation or less. Any serious adverse event (SAE) within 42 days after IA was the primary composite outcome.<\/p>\n The researchers found that in comparison 1, SAEs occurred in 3.3 and 1.8 per 1,000 after mifepristone-misoprostol and procedural IA, respectively (relative risk [RR], 1.87; 95 percent confidence interval [CI], 1.44 to 2.43; absolute risk difference, 1.5 per 1,000). For any adverse event, the corresponding rates were 28.9 and 12.4 per 1,000 (RR, 2.33; 95 percent CI, 2.11 to 2.57; absolute risk difference, 1.65 per 1,000). In comparison 2, there was no significant difference seen in SAEs, which occurred in 3.3 and 3.4 per 1,000 women, respectively (RR, 1.04; 95 percent CI, 0.61 to 1.78). The corresponding rates of any adverse event were 31.2 and 24.9 per 1,000 (RR, 1.25; 95 percent CI, 1.04 to 1.51).<\/p>\n “Although short-term adverse events occur more often after mifepristone-misoprostol IA than procedural IA, the risk for serious adverse outcomes is very small,” the authors write.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n