Only peak force fatigability, but not peak rate of force development, contributed to fatigue variance<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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MONDAY, Dec. 19, 2022 (HealthDay News) — Chronic kidney disease (CKD) is associated with greater neuromuscular fatigability, which increases with fatigue severity, according to a study published online Dec. 9 in Medicine & Science in Sports & Exercise<\/em>.<\/p>\n Antoine Chatrenet, Ph.D., from Le Mans Universit \u00a9 in France, and colleagues examined the etiology of neuromuscular fatigability in a study involving 45 CKD patients and 57 controls. Two questionnaires were used to assess fatigue. During explosive contractions, the peak rate of force development (RFDpeak<\/sub>, normalized: NRFDpeak<\/sub>) and rate of electromyography rise (RER) were measured. During maximum voluntary contractions, peak force and mean surface electromyography were measured.<\/p>\n The researchers found that the main impact of CKD was on the Mental and the Reduced Motivation subscales of fatigue. CKD was associated with greater neuromuscular fatigability measured using NRFDpeak<\/sub>, which increased with the severity of fatigue and with a higher rate of RER decrease compared with controls. An association was seen between the Reduced Motivation subscale and the RER in these patients. Peak force fatigability, but not RFDpeak<\/sub>, contributed to fatigue variance.<\/p>\n “The association between neuromuscular fatigability and self-reported fatigue suggests that exercise interventions such as adapted physical activity might mitigate fatigue and improve quality of life in CKD patients,” the authors write.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n