n-3 fatty acid supplementation may reduce CVD mortality, myocardial infarction, coronary heart disease events<\/p>\n<\/h3>\n
By Elana Gotkine HealthDay Reporter<\/b><\/p>\n
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THURSDAY, Dec. 8, 2022 (HealthDay News) — Supplementation of some micronutrients may reduce cardiovascular disease (CVD) outcomes, according to a review published in the Dec. 13 issue of the Journal of the American College of Cardiology<\/em>.<\/p>\n Peng An, Ph.D., from China Agricultural University in Beijing, and colleagues conducted a systematic review and meta-analysis of randomized controlled intervention trials of micronutrients on CVD risk factors and clinical events. Data were included from 884 trials evaluating 27 types of micronutrients among 883,627 participants.<\/p>\n The researchers found moderate- to high-quality evidence that supplementation with n-3 fatty acid, n-6 fatty acid, L-arginine, L-citrulline, folic acid, vitamin D, magnesium, zinc, \u00ce\u00b1-lipoic acid, coenzyme Q10, melatonin, catechin, curcumin, flavanol, genistein, and quercetin reduced CVD risk factors. Supplementation with n-3 fatty acids reduced CVD mortality, myocardial infarction, and coronary heart disease events (relative risks, 0.93, 0.85, and 0.86, respectively). Supplementation with folic acid reduced stroke risk, while all-cause mortality events were reduced with coenzyme Q10 supplementation (relative risks, 0.84 and 0.68, respectively). Increased all-cause mortality, CVD mortality events, and stroke risk were seen with \u00ce\u00b2-carotene supplementation (relative risks, 1.10, 1.12, and 1.09, respectively).<\/p>\n “The comprehensive evidence map presented here highlights the importance of micronutrient diversity and the balance of benefits and risks in the design of whole food-based dietary patterns to promote cardiometabolic health, which may require cultural adaptations to apply globally,” the authors write.<\/strong><\/p>\n Two authors disclosed financial ties to pharmaceutical and nutrition companies.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n