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WEDNESDAY, Aug. 15, 2018 (HealthDay News) — Broad-based genomic sequencing does not improve survival compared to routine genetic testing among patients with advanced non-small-cell lung cancer (NSCLC), according to a study published in the Aug. 7 issue of the Journal of the American Medical Association<\/i>.<\/p>\n
Carolyn J. Presley, M.D., from The Ohio State University in Columbus, and colleagues compared clinical outcomes between 5,688 patients with advanced NSCLC who received broad-based genomic sequencing and 4,813 patients who received routine testing for EGFR<\/i> mutations and\/or ALK<\/i> rearrangements alone.<\/p>\n
The researchers found that 4.5 percent of patients who received broad-based genomic sequencing received targeted treatment based on testing results, 9.8 percent received routine EGFR<\/i>\/ALK<\/i>-targeted treatment, and 85.1 percent received no targeted treatment. At 12 months, unadjusted mortality rates were 49.2 percent for patients undergoing broad-based genomic sequencing and 35.9 percent for patients undergoing routine testing. There was no significant association between broad-based genomic sequencing and 12-month mortality, according to the results of an instrumental variable analysis.<\/p>\n
“To ensure that new discoveries are able to fulfill their promise, our results suggest further evidence is needed to inform the care of patients with a variety of specific genetic alterations in their tumors before widely disseminating these new paradigms into clinical practice,” a coauthor said in a statement.<\/p>\n
Several authors disclosed financial ties to the pharmaceutical industry.<\/p>\n
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