10 percent povidone-iodine and aqueous 4 percent chlorhexidine gluconate demonstrated similar efficacy in preventing infection after surgical fixation of open fractures<\/p>\n<\/h3>\n
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WEDNESDAY, Nov. 2, 2022 (HealthDay News) — Both 10 percent povidone-iodine and aqueous 4 percent chlorhexidine gluconate are equally effective for preventing postsurgical infections among patients requiring surgery for open fractures, according to a study published in the Oct. 15 issue of The Lancet<\/em>.<\/p>\n Gerard Slobogean, M.D., from University of Maryland School of Medicine in Baltimore, and colleagues compared the effect of aqueous 10 percent povidone-iodine versus aqueous 4 percent chlorhexidine gluconate on the risk for surgical site infection in patients who required surgery for an open fracture. The analysis included 1,683 adults treated with a surgical fixation implant for an open extremity fracture at one of 14 hospitals in Canada, Spain, and the United States (April 8, 2018, to June 8, 2021).<\/p>\n The researchers found that a surgical site infection occurred in 59 of 787 participants randomly assigned to the povidone-iodine group and 58 of 784 randomly assigned to the chlorhexidine gluconate group (odds ratio, 1.11; 95 percent confidence interval, 0.74 to 1.65; P = 0.61; risk difference, 0.6 percent; 95 percent confidence interval, \u00e2\u0080\u00931.4 to 3.4).<\/p>\n “Many surgeons prefer to use povidone-iodine skin preparation for open fractures because of its wide availability as an effective aqueous solution,” Slobogean said in a statement. “Our findings should reassure surgeons that either antiseptic solution is fine to use, and they can base their decision on product availability, cost, or patient contraindications.”<\/p>\n Several authors disclosed financial ties to the medical device industry.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n