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MONDAY, Aug. 13, 2018 (HealthDay News) — An eight-week low-energy diet (LED) induces different effects in men and women, according to a study published online Aug. 7 in Diabetes, Obesity and Metabolism<\/i>.<\/p>\n
Pia Christensen, Ph.D., from the University of Copenhagen in Denmark, and colleagues recruited participants from eight sites who were overweight (body mass index \u226525 kg\/m\u00b2) with prediabetes. Participants followed a LED (810 kcal\/day) for eight weeks.<\/p>\n
A total of 2,224 individuals (1,504 women and 720 men) attended the baseline visit and 2,020 completed follow-up. The researchers found that weight loss was 16 percent greater in men than in women (11.8 versus 10.3 percent) following LED; the improvements in insulin resistance were similar. In men and women, the homeostasis model for assessment of insulin resistance was 1.50 \u00b1 0.15 and 1.35 \u00b1 0.15, respectively, which was not significantly different. Men had larger reductions in metabolic syndrome Z-score, C-peptide, fat mass, and heart rate, after adjustment for differences in weight loss; women had larger reductions in high-density lipoprotein cholesterol, fat-free mass, hip circumference, and pulse pressure. Thirty-five percent of participants of both genders reverted to normo-glycemia following the LED.<\/p>\n
“These findings are clinically important and suggest gender-specific changes after weight loss,” the authors write.<\/p>\n
Several authors disclosed financial ties to nutrition and weight-loss industries.<\/p>\n