L-shaped association for genetically predicted 25(OH)D with all-cause mortality, with risk decreasing up to concentration of 50 nmol\/L<\/p>\n<\/h3>\n
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MONDAY, Oct. 24, 2022 (HealthDay News) — There seems to be a causal relationship between vitamin D deficiency and mortality in U.K. Biobank data, according to a study published online Oct. 25 in the Annals of Internal Medicine<\/em>.<\/p>\n Joshua P. Sutherland, from the University of South Australia in Adelaide, and colleagues examined genetic evidence for the causal role of low vitamin D status in mortality in a prospective cohort of 307,601 U.K. Biobank participants of White European Ancestry, aged 37 to 73 years at recruitment, with available 25-hydroxyvitamin D (25[OH]D) measurements and genetic data.<\/p>\n The researchers identified 18,700 deaths during 14 years of follow-up. There was an L-shaped association observed for genetically predicted 25(OH)D with all-cause mortality; the risk for death decreased steeply with increasing concentrations up to 50 nmol\/L. In analyses of mortality from cancer, cardiovascular disease, and respiratory diseases, there was evidence of an association. In the genetic analysis, the odds of all-cause mortality were estimated to increase significantly for participants with a measured 25(OH)D concentration of 25 nmol\/L versus 50 nmol\/L (odds ratio, 1.25).<\/p>\n “Additional research needs to identify strategies that meet the National Academy of Medicine’s guideline concentration of greater than 50 nmol\/L and that reduce the premature risk for death associated with low vitamin D levels,” the authors write.<\/strong><\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n