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FRIDAY, Aug. 10, 2018 (HealthDay News) — Preconception vitamin D levels may play a role in maintaining pregnancy, according to a study published recently in The Lancet Diabetes & Endocrinology<\/i>.<\/p>\n
Sunni Mumford, Ph.D., from the National Institutes of Health in Bethesda, Md., and colleagues conducted a secondary analysis of data from the EAGeR trial to assess the association between preconception vitamin D and pregnancy outcomes among 1,191 women with proven fecundity. Serum 25-hydroxyvitamin D was measured preconception (baseline) and at 8 weeks gestation.<\/p>\n
The researchers found that 555 women (47 percent) were classified as having sufficient concentrations (\u226575 nmol\/L) while 636 (53 percent) had insufficient concentrations (<75 nmol\/L). Clinical pregnancy was more likely among women with sufficient preconception 25-hydroxyvitamin D (adjusted risk ratio [RR], 1.10) and livebirth (adjusted RR, 1.15) versus women with insufficient concentrations. Among women who achieved pregnancy, sufficient preconception 25-hydroxyvitamin D was associated with reduced risk of pregnancy loss (preconception RR per 25 nmol\/L, 0.88; 95 percent confidence interval, 0.77 to 0.99); but this was not found at 8 weeks of gestation (RR, 0.98; 95 percent confidence interval, 0.95 to 1.01).<\/p>\n
“These results provide valuable insight into the potential effects of vitamin D during the preconception period for fertile or subfertile couples attempting spontaneous conception,” the authors write.<\/p>\n
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