Neoadjuvant therapy with an NHA associated with longer time to biochemical recurrence, prolonged metastasis-free survival<\/p>\n<\/h3>\n
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THURSDAY, Sept. 22, 2022 (HealthDay News) — Neoadjuvant therapy with a novel hormonal agent prior to radical prostatectomy is associated with better outcomes for men with high-risk prostate cancer versus upfront radical prostatectomy, according to a study published in the Oct. 1 issue of The <\/em>Journal of Urology<\/em>.<\/p>\n Praful Ravi, M.D., from the Lank Center for Genitourinary Oncology at the Dana-Farber Cancer Institute in Boston, and colleagues compared outcomes between neoadjuvant therapy with a novel hormonal agent prior to RP (neo-RP) and upfront radical prostatectomy (RP) in patients with high-risk prostate cancer. The analysis included 112 patients in the neo-RP group and 259 in the RP group followed for four years.<\/p>\n The researchers found that after inverse probability of treatment weighting, time to biochemical recurrence (hazard ratio, 0.25) and metastasis-free survival (hazard ratio, 0.26) were significantly longer in the neo-RP versus the RP group. Additionally, in the neo-RP group, rates of adjuvant (7 versus 24 percent) and salvage therapy (34 versus 46 percent) were lower.<\/p>\n “Neoadjuvant therapy with novel hormonal agents before radical prostatectomy is an innovative approach to treatment of prostate cancer with high-risk characteristics,” a coauthor said in a statement. “While we await the results of definitive clinical trials, our findings suggest that this approach can improve key outcomes, compared to starting treatment with radical prostatectomy.”<\/p>\n Several authors disclosed financial ties to pharmaceutical companies, including Janssen, which funded the study.<\/p>\n