Genetic predisposition to psoriasis not linked to total IBD, but is associated with Crohn disease<\/p>\n<\/h3>\n
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THURSDAY, Sept. 22, 2022 (HealthDay News) — Inflammatory bowel disease (IBD) appears to have a causal impact on psoriasis, especially psoriatic arthritis (PsA), and total psoriasis and PsA are associated with Crohn disease (CD), according to a study recently published in the Frontiers of Immunology<\/em>.<\/p>\n Yajia Li, from Central South University in Changsha, China, and colleagues used a mendelian randomization (MR) approach to examine whether there is a causal relationship between IBD and psoriasis. A two-sample MR was conducted with the genetic instruments identified for IBD and its main subtypes, CD and ulcerative colitis (UC), using data from a genome-wide association study (GWAS) with 25,042 IBD cases and 34,915 controls. Summarized psoriasis data were obtained from GWAS studies with 4,510 psoriasis cases and 212,242 controls. <\/p>\n The researchers found that genetic predisposition to IBD was associated with increased psoriasis risk (odds ratio, 1.1271). A significant association was seen for PsA with total IBD (odds ratio, 1.1202). Causal relationships were also observed for CD-psoriasis and CD-PsA (odds ratios, 1.1552 and 1.1407, respectively). A genetic predisposition to psoriasis was not associated with total IBD; however, psoriasis was associated with CD (odds ratio, 1.2224) but not UC. There was a borderline association observed for genetic predisposition to PsA with IBD (odds ratio, 1.0716), and a suggestive association was observed with CD (odds ratio, 1.0667).<\/p>\n “Understanding that specific types of psoriasis and IBD constitute mutual risk factors facilitates early diagnosis enabling more efficient targeting of therapy,” the authors write.<\/p>\n