After full adjustment, association between influenza vaccination and ischemic stroke yielded adjusted odds ratio of 0.88<\/p>\n<\/h3>\n
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WEDNESDAY, Sept. 7, 2022 (HealthDay News) — Influenza vaccination seems to have a moderate protective effect on ischemic stroke, according to a study published online Sept. 7 in Neurology<\/em>.<\/p>\n Sara Rodr \u00adguez-Mart \u00adn, Pharm.D., Ph.D., from the University of Alcal \u00a1 in Madrid, and colleagues conducted a nested case-control study to examine the association between influenza vaccination and risk for a first ischemic stroke during pre-epidemic, epidemic, and postepidemic periods. The source cohort included individuals aged 40 to 99 years with at least one-year registry and no history of stroke or cancer; five controls were randomly selected per case, matched for exact age, sex, and date of stroke diagnosis (index date; 14,322 incident ischemic stroke cases and 71,610 matched controls).<\/p>\n The researchers found that 41.4 and 40.5 percent of the cases and controls, respectively, were vaccinated, yielding a crude odds ratio of 1.05. Vaccinated individuals had a higher prevalence of vascular risk factors, disease, and comedication; after full adjustment, the association of influenza vaccination with ischemic stroke yielded an adjusted odds ratio of 0.88, which appeared early (adjusted odds ratio15 to 30 days<\/sub>, 0.79) and decreased over time (adjusted odds ratio>150 days<\/sub>, 0.92). The reduced risk was of similar magnitude for noncardioembolic and cardioembolic stroke, in all three epidemic periods and in all subgroups.<\/p>\n “These results are yet another reason for people to get their yearly flu shot, especially if they are at an increased risk of stroke,” a coauthor said in a statement. “To be able to reduce your risk of stroke by taking such a simple action is very compelling.”<\/p>\n Several authors disclosed financial ties to Sanofi.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n <\/p>\n <\/i><\/p>\n