Lifestyle factors not tied to overall diagnosis of prostate cancer<\/p>\n<\/h3>\n
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FRIDAY, July 15, 2022 (HealthDay News) — Adherence to a healthy lifestyle is associated with close to a 50 percent lower risk for developing lethal prostate cancer among men at high risk for the disease, according to a study recently published in European Urology<\/em>.<\/p>\n Anna Plym, Ph.D., from Brigham and Women s Hospital in Boston, and colleagues examined whether men at an increased genetic risk for prostate cancer can offset their risk for disease or disease progression by adhering to a healthy lifestyle. The analysis included 12,411 genotyped men participating in the Health Professionals Follow-up Study (1993 to 2019) and the Physicians Health Study (1983 to 2010).<\/p>\n The researchers found that the polygenic risk score (PRS) enabled risk stratification not only for overall prostate cancer but also for lethal disease, with a fourfold difference between men in the highest and lowest quartiles (hazard ratio, 4.32). Adhering to a healthy lifestyle was associated with a decreased rate of lethal prostate cancer (hazard ratio, 0.55) for men in the highest PRS quartile compared with having an unhealthy lifestyle, yielding a lifetime risk of 1.6 percent among the healthy men and 5.3 percent among the unhealthy men. There was no association seen between adhering to a healthy lifestyle and a decreased risk for overall prostate cancer.<\/p>\n “Having a high genetic risk is often viewed as something very deterministic, but our findings suggest it may not be,” Plym said in a statement. “Through lifestyle modifications, early screening, and early treatment we may be able to deal with high genetic risks.”<\/p>\n