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WEDNESDAY, Aug. 1, 2018 (HealthDay News) — Tamsulosin does not significantly increase the urinary stone passage rate compared with placebo, according to a study published online June 18 in JAMA Internal Medicine<\/i>.<\/p>\n
Andrew C. Meltzer, M.D., from the George Washington University School of Medicine & Health Sciences in Washington, D.C., and colleagues randomized 512 patients presenting in an emergency department with symptomatic urinary stone in the ureter (<9 mm in diameter) to treatment with either tamsulosin (0.4 mg) or placebo daily for 28 days.<\/p>\n
The researchers found that stone passage rates were 50 percent in the tamsulosin group and 47 percent in the placebo group (relative risk, 1.05; 95.8 percent confidence interval, 0.87 to 1.27; P = 0.60). No secondary outcomes (time to stone passage, return to work, use of analgesic medication, hospitalization, surgical intervention, and repeated emergency department visit) were significant.<\/p>\n
“For emergency department patients who present with renal colic owing to ureteral stones smaller than 9 mm, tamsulosin does not appear to promote stone passage,” the authors write. “Guidelines for medical expulsive therapy for urinary stones may need to be revised.”<\/p>\n
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