Almost 40 percent of those with ADNC had limbic-predominant age-related TDP-43 encephalopathy neuropathologic change<\/p>\n<\/h3>\n
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MONDAY, June 20, 2022 (HealthDay News) — Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is seen in almost 40 percent of brains with Alzheimer disease neuropathologic change (ADNC), according to a study published online June 13 in Acta Neuropathologica.<\/em><\/p>\n Peter T. Nelson, M.D., Ph.D., from the Sanders\u00e2\u0080\u0091Brown Center on Aging at the University of Kentucky in Lexington, and colleagues compiled neuropathologic, genetic, and clinical data from 13 high-quality community- and population-based longitudinal studies, including a total of 6,196 participants, to examine the prevalence of LATE-NC across the full range of ADNC.<\/p>\n The researchers found that among the 6,125 participants with available CERAD neuritic amyloid plaque score data, 39.4 percent had autopsy-confirmed LATE-NC of any stage. Of the brains with frequent neuritic amyloid plaques, 54.9 percent had comorbid LATE-NC compared with 27.0 percent of brains with no detected neuritic amyloid plaques. Brains with LATE-NC had relatively more severe primary age-related tauopathy in the subset of individuals with Tha1 A\u00ce\u00b2 phase = 0 (lacking detectable A\u00ce\u00b2 plaques). Cognition tended to be worse with LATE-NC across the full spectrum of ADNC severity in the 10 cohorts with detailed neurocognitive assessments close to death.<\/p>\n “These data are interpreted to indicate that LATE-NC, with or without comorbid ADNC, is highly prevalent and impactful in persons of advanced age,” the authors write.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n