Patients with rs2814778-CC also have lower last leukocyte count and lower dosing; findings persist after adjustment for race<\/p>\n<\/h3>\n
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MONDAY, June 20, 2022 (HealthDay News) — Patients with the rs2814778-CC genotype have higher risks for azathioprine discontinuation attributed to hematopoietic toxicity, even after adjustment for race, according to a study published online June 21 in the Annals of Internal Medicine.<\/em><\/p>\n Alyson L. Dickson, from the Vanderbilt University Medical Center in Nashville, Tennessee, and colleagues conducted a retrospective cohort study to examine whether rs2814778-CC was associated with azathioprine discontinuation attributed to hematopoietic toxicity among thiopurine users of White or Black race.<\/p>\n The researchers found that among 101 patients with the CC genotype, the rate of azathioprine discontinuation attributed to hematopoietic toxicity was 3.92 per 100 person-years compared with 1.34 per 100 person-years among the 1,365 patients with the TT or TC genotype (hazard ratio from competing-risk model, 2.92; 95 percent confidence interval [CI], 1.57 to 5.41). After adjustment for race, the risk remained significant (hazard ratio, 2.61; 95 percent CI, 1.01 to 6.71). The risk associated with race alone (hazard ratio, 2.13; 95 percent CI, 1.21 to 3.75) was abrogated after genotype adjustment (hazard ratio, 1.13; 95 percent CI, 0.48 to 2.69). Among patients with the CC genotype, last leukocyte count and dosing were significantly lower.<\/p>\n “The next steps for research will be to study whether specific lower leukocyte counts with the rs2814778-CC genotype are associated with greater risks for infection and, if not, whether different leukocyte thresholds are appropriate for discontinuation or dose reduction,” the authors write.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n