Risk factors for incident T2D include female gender, BMI z-score, and more severe liver histology, including steatosis grade, fibrosis stage<\/p>\n<\/h3>\n
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TUESDAY, June 21, 2022 (HealthDay News) — Children with nonalcoholic fatty liver disease (NAFLD) have a high risk for existing and incident type 2 diabetes (T2D), with a prevalence of 16.8 percent, according to a study published online June 13 in Clinical Gastroenterology and Hepatology.<\/em><\/p>\n Kimberly P. Newton, M.D., from the University of California San Diego School of Medicine in La Jolla, and colleagues examined the incidence of T2D in children with NAFLD in a longitudinal follow-up of 892 children enrolled in the Nonalcoholic Steatohepatitis Clinical Research Network. Participants were followed for 3.8 years, with a total of 3,234 person-years at risk.<\/p>\n The researchers found that the incidence rate was 3,000 new cases of T2D per 100,000 person-years at risk. Sixty-three children had T2D at baseline, and an additional 97 children developed T2D during follow-up, resulting in a period prevalence of 16.8 percent. Incident T2D was significantly higher for girls versus boys (hazard ratio, 1.8), in association with body mass index z-score (hazard ratio, 1.8), and with more severe liver histology, including steatosis grade and fibrosis stage (hazard ratios, 1.3 and 1.3, respectively).<\/p>\n “There is a growing public health crisis as children with diabetes mature into adults with diabetes,” a coauthor said in a statement. “We need to better understand how NAFLD contributes to type 2 diabetes risk in children so that we can actively work to prevent it.”<\/p>\n Several authors disclosed financial ties to the pharmaceutical industry.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n