Five-year freedom from progression rate higher for those receiving short-term ADT and PLNRT in addition to salvage PBRT<\/p>\n<\/h3>\n
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THURSDAY, June 9, 2022 (HealthDay News) — The addition of androgen deprivation therapy (ADT) and pelvic lymph node radiotherapy (PLNRT) to prostate bed radiotherapy (PBRT) prolongs freedom from progression of prostate cancer following prostatectomy, according to a study published in the May 14 issue of The Lancet<\/em>.<\/p>\n Alan Pollack, M.D., from the University of Miami Miller School of Medicine, and colleagues conducted an international randomized trial involving patients with a persistently detectable or an initially undetectable and rising prostate-specific antigen of 0.1 to 2.0 ng\/mL after prostatectomy for adenocarcinoma of the prostate. A total of 1,792 patients were enrolled and randomly assigned to PBRT alone (group 1), PBRT plus short-term ADT (group 2), or PLNRT plus PBRT and short-term ADT (group 3; 592, 602, and 598 patients, respectively). The evaluable patient population included 1,716 patients.<\/p>\n The researchers found that at the interim analysis, when group 1 was compared to group 3, the Haybittle-Peto boundary for five-year freedom from progression was exceeded (difference, 17.9 percent). Comparing groups 2 and 3, the difference did not exceed the boundary. At a median follow-up of 8.2 years, which was beyond the interim analysis, the five-year freedom from progression rates were 70.9, 81.3, and 87.4 percent in groups 1, 2, and 3, respectively. Freedom from progression was superior in group 3 versus groups 1 and 2 per protocol criteria.<\/p>\n “Extension of the standard postprostatectomy salvage prostate bed radiotherapy fields to include the pelvic lymph nodes, when used in combination with short-term ADT, was found to result in the greatest impact on outcomes,” the authors write.<\/p>\n Several authors disclosed financial ties to the pharmaceutical industry.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n