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THURSDAY, July 19, 2018 (HealthDay News) — Both high and low uric acid levels are associated with an increased risk of dying, according to a study published in the July issue of Arthritis & Rheumatology<\/i>.<\/p>\n
Sung Kweon Cho, M.D., Ph.D., from Sungkyunkwan University in Seoul, South Korea, and colleagues evaluated the association between uric acid levels and the risk of all-cause and cause-specific mortality among 375,163 Korean adults over a range of uric acid levels using national health records (2002 to 2012).<\/p>\n
The researchers found that over the study period (2,060,721.9 person-years), 2,020 participants died, with 287 cardiovascular disease (CVD)-related deaths and 963 cancer deaths. Both low and high uric acid levels were associated with increased all-cause, CVD, and cancer mortality. For all-cause mortality in the lowest uric acid categories (<3.5 mg\/dL for men and <2.5 mg\/dL for women) versus the sex-specific reference category, multivariable-adjusted hazard ratios were 1.58 and 1.80, respectively. For the highest uric acid categories (\u22659.5 mg\/dL for men and \u22658.5 mg\/dL for women), the corresponding hazard ratios were 2.39 and 3.77.<\/p>\n
“In this large cohort study of men and women, both low and high uric acid levels were predictive of increased mortality, supporting a U-shaped association between serum uric acid levels and adverse health outcomes,” the authors write.<\/p>\n
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