Normal-appearing skin is type I interferon-rich environment; interferon-induced gene expression changes seen in all major skin type cells<\/p>\n<\/h3>\n
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TUESDAY, May 10, 2022 (HealthDay News) — For patients with cutaneous lupus erythematosus (CLE), normal-appearing skin is a type I interferon-rich, prelesional environment, according to a study published in the April 27 issue of Science Translational Medicine<\/em>.<\/p>\n Allison C. Billi, M.D., Ph.D., from the University of Michigan in Ann Arbor, and colleagues analyzed normal-appearing skin, lesional skin, and circulating immune cells from lupus patients via integrated single-cell RNA sequencing and spatial RNA sequencing to examine CLE immunopathogenesis.<\/p>\n The researchers found that in patients with lupus, normal-appearing skin represented a type I interferon-rich, prelesional environment. Interferon-induced gene expression changes were seen in all major skin cell types and altered predicted cell-cell communication networks. In addition, lupus-enriched CD16+ dendritic cells underwent interferon education in the skin, yielding proinflammatory phenotypes.<\/p>\n “These interferon-educated immune cells seem to be priming many different cell types in the skin to overreact to stimuli with excessive inflammatory responses, manifesting as disfiguring skin lesions,” Billi said in a statement. “We don’t yet know all of the stimuli that can tip the balance and precipitate these rashes, but ultraviolet light certainly appears to be one of them.”<\/p>\n Several authors disclosed financial ties to the biopharmaceutical industry.<\/p>\n