Findings for severity of symptoms such as incontinence and frequent nighttime urination, regardless of bothersomeness<\/p>\n<\/h3>\n
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TUESDAY, May 3, 2022 (HealthDay News) — Moderate-to-severe male lower urinary tract symptoms (LUTS) are associated with an increased risk of death during long-term follow-up, according to a study published online April 26 in The Journal of Urology<\/em>.<\/p>\n Jonne \u0085kerla, M.D., from Tampere University Hospital in Finland, and colleagues evaluated LUTS-associated mortality among Finnish men. Analysis included responses from 1,167 men (aged 50, 60, and 70 years in 1994), with repeat surveys conducted in 1999, 2004, 2009, and 2015.<\/p>\n The researchers observed an association for increased mortality with overall voiding and storage LUTS, daytime frequency, and urgency incontinence, with adjusted hazard ratios of 1.19 (95 percent confidence interval [CI], 1.00 to 1.40), 1.35 (1.13 to 1.62), 1.31 (1.09 to 1.58) and 2.19 (1.42 to 3.37), respectively, when limited to moderate and severe symptoms. When disregarding symptom severity and bother, voiding LUTS were associated with decreased mortality (HR, 0.82; 95 percent CI, 0.67 to 1.00), while daytime frequency and nocturia were associated with increased mortality (HRs, 1.31 [95 percent CI, 1.09 to 1.58] and 1.52 [95 percent CI, 1.21 to 1.91], respectively). When examining bothersome daytime frequency and nocturia, excess mortality tended to be slightly higher (HRs, 1.86 [95 percent CI, 1.41 to 2.47] and 1.88 [95 percent CI, 1.38 to 2.58], respectively). <\/p>\n “The lack of association between symptom bother and mortality possibly reinforces the very subjective nature of bother as a construct compared to more objectively measured symptom severity,” the authors write.<\/p>\n