Possible negative association of history of antibiotic prescriptions with vaccine-induced immunity seen in young children<\/p>\n<\/h3>\n
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WEDNESDAY, April 27, 2022 (HealthDay News) — Antibiotic prescriptions for children aged 6 to 24 months are associated with reduced vaccine-induced immunity, according to a study published online April 27 in Pediatrics<\/em>.<\/p>\n Timothy J. Chapman, Ph.D., from the Rochester General Hospital Research Institute in New York, and colleagues observed 560 children aged 6 to 24 months in a cohort study from 2006 to 2016 to examine the association between antibiotic use and vaccine-induced immunity. A retrospective unplanned, secondary analysis of medical records was undertaken concurrently regarding antibiotic prescriptions and vaccine antibody measurements.<\/p>\n Among 560 children, 342 had and 218 had not received antibiotic prescriptions. The researchers found that children given antibiotics had lower vaccine-induced antibody levels to several diphtheria-tetanus-acellular pertussis (DTaP) and pneumococcal conjugate (PCV) antigens. At 9 and 12 months of age, a higher frequency of vaccine-induced antibodies below protective levels was seen in children given antibiotics. There was a negative association observed for antibiotic courses over time with vaccine-induced antibody levels. For each antibiotic course the child received, prebooster antibody levels decreased by 5.8, 6.8, 11.3, and 10.4 percent to DTaP, Haemophilus influenzae <\/em>type b, inactivated polio, and PCV antigens, respectively, while postbooster antibody levels were reduced by 18.1, 21.3, 18.9, and 12.2 percent, respectively.<\/p>\n “We provide new evidence to suggest caution about overprescribing antibiotics because an adverse effect seems to extend to reduction in vaccine responses,” the authors write.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n Editorial (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n