Blood pressure hyperreactivity to standing independently predicts major adverse cardiovascular and renal events in young hypertensive adults<\/p>\n<\/h3>\n
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FRIDAY, March 18, 2022 (HealthDay News) — For young hypertensive adults, blood pressure hyperreactivity to standing is associated with major adverse cardiovascular and renal events, according to a study published online March 17 in Hypertension<\/em>.<\/p>\n Paolo Palatini, M.D., from the University of Padova in Italy, and colleagues examined the association of orthostatic hyperreactivity with major adverse cardiovascular and renal events in a cohort of 1,207 untreated individuals screened for stage I hypertension (mean age, 33.1 \u00c2\u00b1 8.6 years). The definition of hyperreactivity to standing was a standing-supine blood pressure (BP) difference in the top decile.<\/p>\n The researchers found that compared with normoreactors, hyperreactors more often had ambulatory hypertension (90.8 versus 76.4 percent). The epinephrine\/creatinine ratio was higher in hyperreactors among the 630 participants in whom 24-hour urinary catecholamines were measured. A total of 105 major adverse cardiovascular and renal events were accrued during a 17.2-year follow-up. Hyperreactivity to standing was an independent predictor of major adverse cardiovascular and renal events in a multivariate model, with a hazard ratio of 1.97. When ambulatory BP data and incident hypertension during follow-up were included in the model, hyperreactivity remained an independent predictor of adverse events (hazard ratio, 1.94).<\/p>\n “The results of the study confirmed our initial hypothesis — a pronounced increase in blood pressure from lying to standing could be prognostically important in young people with high blood pressure,” Palatini said in a statement. “We were rather surprised that even a relatively small increase in standing blood pressure (6 to 7 mm Hg) was predictive of major cardiac events in the long run.”<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n