Exercise benefits extend beyond liver-related outcomes, independent of weight loss or dietary change<\/p>\n<\/h3>\n
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TUESDAY, March 8, 2022 (HealthDay News) — Exercise may help patients with nonalcoholic steatohepatitis (NASH) reduce their risk for developing blood clots, according to a study recently published in Hepatology<\/em>.<\/p>\n Jonathan G. Stine, M.D., from Pennsylvania State University in Hershey, and colleagues randomly assigned patients with biopsy-confirmed NASH to either an exercise training program (18 patients) or standard clinical care (10 patients).<\/p>\n The researchers found that the plasminogen activator inhibitor 1 level was significantly decreased with exercise training versus standard clinical care (\u00e2\u0088\u009240 versus +70 ng\/mL). Exercise training was also associated with decreased magnetic resonance imaging proton density fat fraction (MRI-PDFF), with 40 percent of exercise participants having a \u00e2\u0089\u00a530 percent relative reduction in MRI-PDFF (histological response threshold) versus 13 percent among those receiving standard of care. Lastly, exercise training was associated with improved fitness (as measured by VO2<\/sub> peak) versus standard clinical care.<\/p>\n “Independent of weight loss or dietary change, exercise training resulted in a significantly greater decrease in thrombotic risk than standard clinical care in patients with NASH,” the authors write.<\/p>\n One author disclosed financial ties to the pharmaceutical industry.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n