{"id":754,"date":"2018-02-15T00:00:00","date_gmt":"2018-02-15T00:00:00","guid":{"rendered":"http:\/\/medgoo.com\/index.php\/2018\/02\/15\/induced-pluripotent-stem-cell-vaccine-promising-for-cancer\/"},"modified":"2018-02-16T17:09:57","modified_gmt":"2018-02-16T17:09:57","slug":"induced-pluripotent-stem-cell-vaccine-promising-for-cancer","status":"publish","type":"post","link":"https:\/\/medgoo.com\/index.php\/2018\/02\/15\/induced-pluripotent-stem-cell-vaccine-promising-for-cancer\/","title":{"rendered":"Induced Pluripotent Stem Cell Vaccine Promising for Cancer"},"content":{"rendered":"<h3>iPSC vaccine prevented tumor growth in syngeneic murine breast CA, mesothelioma, melanoma models<\/h3>\n<p><b><\/b><\/p>\n<p><b><\/b><\/p>\n<p>THURSDAY, Feb. 15, 2018 (HealthDay News) &#8212; Induced pluripotent stem cell (iPSC) vaccines prevent tumor growth in syngeneic murine cancer models in a prophylactic setting, according to a study published online Feb. 15 in <i>Cell Stem Cell<\/i>.<\/p>\n<p>Noting that it may be possible for iPSCs to be harnessed to elicit anti-tumor responses in cancer vaccines, Nigel G. Kooreman, M.D., from the Stanford University School of Medicine in California, and colleagues conducted a proof-of-principle study for using irradiated iPSCs in autologous anti-tumor vaccines.<\/p>\n<p>The researchers found that iPSC vaccines prevented tumor growth in syngeneic murine breast cancer, mesothelioma, and melanoma models in a prophylactic setting. The iPSC vaccine inhibited melanoma recurrence at the resection site as an adjuvant and reduced metastatic tumor load, which was correlated with fewer Th17 cells and increased CD11b<sup>+<\/sup>GR1<sup>hi<\/sup> myeloid cells. Adoptive transfer of T cells isolated from tumor-bearing mice treated with the vaccine inhibited growth of tumors in unvaccinated recipients.<\/p>\n<p>&#8220;Our data suggest a generalizable strategy for multiple types of cancer that could prove highly valuable in clinical immunotherapy,&#8221; the authors write.<\/p>\n<p><a href=\"https:\/\/www.cell.com\/cell-stem-cell\/fulltext\/S1934-5909(18)30016-X\" target=\"_new\">Abstract\/Full Text<\/a><\/p>\n<p><i><\/i><\/p>\n<p><i>Copyright \u00a9 2018 <a href=\"https:\/\/www.healthday.com\/\" target=\"_new\">HealthDay<\/a>. All rights reserved.<\/i>   <\/p>\n","protected":false},"excerpt":{"rendered":"<p>iPSC vaccine prevented tumor growth in syngeneic murine breast CA, mesothelioma, melanoma models<\/p>\n","protected":false},"author":6,"featured_media":775,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[11],"class_list":["post-754","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","tag-news"],"_links":{"self":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts\/754","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/comments?post=754"}],"version-history":[{"count":1,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts\/754\/revisions"}],"predecessor-version":[{"id":774,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/posts\/754\/revisions\/774"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/media\/775"}],"wp:attachment":[{"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/media?parent=754"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/categories?post=754"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/medgoo.com\/index.php\/wp-json\/wp\/v2\/tags?post=754"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}