CRP cutoff of \u226512 mg\/L equivalent to ESR >30 mm\/h as one of the criteria used to define the severity of an acute attack of ulcerative colitis<\/p>\n<\/h3>\n
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THURSDAY, Feb. 17, 2022 (HealthDay News) — A C-reactive protein (CRP) cutoff is a sensitive and practical alternative to erythrocyte sedimentation rate (ESR) as a criterion to help determine ulcerative colitis (UC) activity, according to a study published online Feb. 11 in the Journal of Crohn’s and Colitis<\/em>.<\/p>\n Anthony Croft, M.B.B.S., from the Royal Brisbane and Women’s Hospital in Australia, and colleagues examined the equivalent CRP cutoff for an ESR of >30 mm\/h using data from 163 presentations with severe UC. Confusion matrices were used to determine the corresponding CRP cutoff. Data were analyzed from a validation cohort comprising 128 presentations.<\/p>\n The researchers found that a CRP cutoff of \u00e2\u0089\u00a512 mg\/L yielded a positive predictive value (PPV) of 85 percent, with sensitivity and accuracy of 95 and 82 percent, respectively, for having a paired ESR of >30 mm\/h. No statistically significant differences were seen in presenting fecal calprotectin, Mayo endoscopic subscore, or in the rates of intravenous corticosteroid therapy failure and colectomy-by-discharge for the groups determined by traditional ESR versus the new CRP-based criteria. A PPV of 83 percent and sensitivity of 94 percent resulted from application of the CRP \u00e2\u0089\u00a512 mg\/L criterion to the validation cohort. <\/p>\n “This work may influence clinical practice by relegating ESR as an admission blood test in acute presentations of UC,” the authors write. “Utilizing the CRP-based criteria will improve accessibility to the clinical information required for a complete assessment of the Truelove and Witts Criteria. This will enable a shorter turnaround time for critical decision making regarding patient disposition and management.”<\/p>\n One author disclosed financial ties to the pharmaceutical industry.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n