Longer duration of oral contraceptive use, certain types of tubal ligation associated with lower levels of antim\u00fcllerian hormone<\/p>\n<\/h3>\n
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WEDNESDAY, Feb. 16, 2022 (HealthDay News) — The long-term use of oral contraceptives (OCs) and certain methods of tubal ligation are associated with lower levels of a biomarker for ovarian function, possibly suggesting a link to early menopause, according to a study published in the February issue of Menopause<\/em>.<\/p>\n Christine R. Langton, Ph.D., from the University of Massachusetts in Amherst, and colleagues examined the association of OC use and tubal ligation with antim \u00bcllerian hormone (AMH), a marker of ovarian aging. The analysis included 1,420 premenopausal participants in the Nurses’ Health Study II who provided a blood sample in 1996 to 1999.<\/p>\n The researchers found that when adjusting for smoking, reproductive events, and other lifestyle factors, there was a significant, inverse association between duration of OC use and mean AMH levels. AMH levels were significantly lower in women with versus without a tubal ligation, when the tubal ligation included a clip, ring, or band (1.04 ng\/mL versus 1.72 ng\/mL). There was no association between AMH levels and age at first use of OCs or age at tubal ligation.<\/p>\n “Further research is warranted to confirm the long-term association of these widely used contraceptive methods with AMH,” the authors write.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n