No increased risk for tinnitus seen with low-dose aspirin, but increase seen with moderate-dose aspirin for those younger than 60 years, NSAIDS, acetaminophen<\/p>\n<\/h3>\n
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THURSDAY, Feb. 10, 2022 (HealthDay News) — The risk for tinnitus is not increased in association with frequent low-dose aspirin use, but it is increased with moderate-dose aspirin and with frequent nonsteroidal anti-inflammatory drug (NSAID) and acetaminophen use, according to a study published online Feb. 7 in the Journal of General Internal Medicine<\/em>.<\/p>\n Sharon G. Curhan, M.D., from Brigham and Women’s Hospital in Boston, and colleagues examined independent associations of aspirin, NSAID, and acetaminophen use with the risk for incident persistent tinnitus in a longitudinal cohort study involving 69,455 women aged 31 to 48 years from the Nurses’ Health Study II.<\/p>\n The researchers identified 10,452 cases of incident persistent tinnitus after 1,120,936 person-years of follow-up. The risk for developing persistent tinnitus was not increased among frequent low-dose aspirin users. Frequent use of moderate-dose aspirin was associated with an increased risk for tinnitus among women aged younger than 60 years but not among older women, with a multivariable-adjusted hazard ratio (HR) of 1.16 for those using moderate-dose aspirin six to seven days\/week versus less than one day\/week. Frequent nonaspirin NSAID or acetaminophen use was associated with an increased risk among all women, with multivariable-adjusted HRs of 1.17 and 1.07 for NSAID use four to five and six to seven days\/week, respectively, versus less than one day\/week, and a multivariable-adjusted HR of 1.18 for acetaminophen use six to seven versus less than one day\/week.<\/p>\n “Our findings suggest that analgesic users may be at higher risk for developing tinnitus and may provide insight into the precipitants of this challenging disorder,” Curhan said in a statement.<\/p>\n Two authors disclosed financial ties to the pharmaceutical industry; one author also disclosed ties to UpToDate.<\/p>\n Abstract\/Full Text (subscription or payment may be required)<\/a><\/p>\n <\/i><\/p>\n